Our Mission:To discover,apply and disseminate knowledge through creative and innovative health research.

On 24th September 2019, the first volunteer was enrolled in the IAVI-W001 study at the KAVI-Institute of Clinical Research (KAVI-ICR) of the University of Nairobi.  The occasion marks the beginning of the 12th HIV vaccine clinical trial to be conducted at KAVI-ICR since 2001. This is a first-in-human study that uses a Native-trimer HIV envelope design that will hopefully stimulate broadly neutralizing antibodies against HIV. KAVI-ICR joins two other research institutes – The Ragon Institute of MGH, MIT and Harvard and the Fred Hutchinson Cancer Research Center-Seattle HIV Vaccine Unit- both in the USA which have already enrolled volunteers into the study.

 

 

Hannah Gakure and Dorothy Essendi confirm prescription before administration

First volunteer enrolled into IAVI-W001 receives the study vaccine

This study also marks a critical milestone of longstanding support from the International AIDS Vaccine Initiative (IAVI) which spans over 20years. HIV continues to devastate communities in Africa in spite of the strides made in prevention and treatment. And even as the prospect of developing a vaccine against HIV/AIDS remains challenging, KAVI-ICR and its partners remain singularly focussed in achieving this goal. KAVI-ICR remains committed to supporting the global effort to develop a safe, effective and affordable HIV vaccine by collaborating with international partners to conduct high impact clinical research. The work at KAVI-ICR would not be possible without the unwavering support from a dedicated team of peer recruiters from the various communities that have stood shoulder to shoulder with the staff at KAVI-ICR through the years.

 

KAVI-KNH Clinic staff mark the start of IAVI Protocol W001

Front Row (L to R): Elizabeth Mueni (Study Coordinator), Catherine Kamau (Pharmacy), Timothy Kotikot (Clinician) Gaudensia Mutua (Clinical Trials Team leader); Jacklyn Nyange (Regulatory Compliance)

Back Row (L to R): Roselyn Malogo & Sharon Lipesa (Community liaison officers), Hilda Ogutu (Snr N/Counsellor), James Wakonyo (Pharmacy), Dorothy Essendi (Assist. Study Coordinator), Emmanuel Museve (Clinician & Safety Officer)

Missing: Hannah Gakure (N/Counsellor) 

 

For more information about this study and other studies being conducted at KAVI-ICR visit our offices at the University of Nairobi, College of Health Sciences at the Kenyatta National Hospital or call +254722207417 and ask to speak to a clinic staff member.

Related links:      

https://clinicaltrials.gov/ct2/show/NCT03699241

https://www.iavi.org/newsroom/press-releases/2019/iavi-w001-clinical-trial-announcement

 

 

Mr.J.Mauti (Ward Admin) (Lt) Zangalewa troupe ready to join the Salvation Army band to start the “walk” Mukuru Kwa Njenga Assist County Commissioner office.

The HIV Vaccine Awareness Day (HVAD) is also known as World AIDS Vaccine Day (WAVD) is commemorated annually on 18th May worldwide. KAVI-Institute of Clinical Research (KAVI-ICR) - University of Nairobi and its partners are cognizant of the influence of communities surrounding study participants and potential participants-(from the grassroots to global stakeholders) and the importance of the community in research and development for HIV/AIDS vaccine.

HIV research also includes efforts to develop a vaccine for HIV treatment (therapeutic vaccine). A safe and effective therapeutic HIV vaccine could prevent HIV from advancing to AIDS, replace daily use of HIV medicines, and help eliminate HIV from the body. This year the theme of the day was “Advancing science to develop HIV vaccine – I am proud to support efforts to end AIDS”.

This year, KAVI-ICRIAVI and in collaboration with Vijana Amani Pamoja (VAP) and the Mukuru community held a football tournament match dubbed “the mbuzi tournament challenge” for adolescents/youth to commemorate the occasion. VAP is a community-based Organization that offers vocational training for the youth i.e. catering, hairdressing, and beauty.VAP also uses football as an educational tool and employs innovative methods and skills for preventing the spread of HIV/AIDS. The event took place at Chaminade grounds next to Mukuru police station. This event was also dubbed “Kick and Test” and HIV Testing services were carried out by Eastern Deanary AIDS Relief Programme (EDARP). There were thirty-two teams that played amid speeches and entertainment. The occasion was graced by the Mukuru Kwa Njenga ward administrator Mr. Jeremiah Mauti. The winning team (SHOFCO) was given the “mbuzi”, a trophy, a ball and gold coated medals to each player. The number two team was awarded silver medals, a ball and a trophy whereas the team that won the third position was awarded a ball and silver medals. The day was rainy and muddy but did not deter anyone who purposes to attend and commemorate the day from participating.

Achievements of the day.

1.34 young people tested

2. Support from the community& administration

3. Establishment of new partnership-VAP

4. Community sensitization about KAVI-ICR

 

Challenges of the day

1. The day was rainy and muddy making it difficult to access the venue

2. The community members had an emergency meeting and wanted to use the same venue.

 

Recommendations

1. To continue involving communities in KAVI-ICR activities-this is key as good rapport with communities enhances understanding.

2. Community staff to be bought for protective footwear.

3. To continue identifying and work with organizations that share and enhance KAVI-ICR’s agenda.

 

Initiation of the Collaboration between NCBS (India) and KAVI-ICR (University Of Nairobi, Kenya) while training University of Nairobi staff on flow cytometry 19th to 23rd March 2018.

 

National Centre for Biological Sciences (NCBS)-India and KAVI-Institute of Clinical Research (KAVI-ICR)

NCBS (India) and KAVI-ICR (University of Nairobi, Kenya) have established and initiated a collaboration to spearhead the following;

  • Expand metagenomics sequencing from selected target groups in India and Africa and inform the newly emerging pathogens (Chikungunya, Dengue & others) in their virology, pathology, a point of care diagnostics and vaccine designs
  • Facilitate vaccine manufacture of existing vaccines in Africa
  • Facilitate the Dengue programs using some of the existing facilities such as the animal house, screening program, imaging, flow units, and genomics.
  • Enabling the NCBS and KAVI-ICR off campus and hospital/community engagements with an evolving data science perspective
  • Exploring the additional use of novel cutting-edge technologies that NCBS is currently using such as next-generation sequencing technologies to evolve therapeutic vaccines
  • Joint development of infrastructure and research
  • Joint teaching arrangements for postgraduate programmes
  • Joint supervision of Postgraduate projects
  • Student and faculty, exchange
  • Joint application for funding including donor funds, research grants, contributions subscriptions
  • Participation in joint academic seminars, training, meetings including participation with other collaborators
  • Any other collaborative efforts as may be determined from time to time.
  • Operational guidelines both academic and budgetary for each activity under the MOU shall be set down in a specific letter of agreement.

 

HIV Vaccine Awareness Day May 2018

Processional march to mark HIV Vaccine Awareness Day in Kangemi on 18th May 2018

Every year on 18th May, the world marks the HIV Vaccine Awareness Day (HVAD). It is a day set aside to raise awareness of the continuing efforts by scientists to develop a vaccine against HIV- the virus that causes AIDS. It is also a day to honour all those who, in one way or the other, have contributed towards this global effort. This year, KAVI-Institute of clinical research (KAVI-ICR) of the University of Nairobi commemorated the day in Nairobi at the Kangemi Health centre.

The day started with a procession from Kangemi health centre (where the KAVI-ICR Kangemi research clinic is located) and was led by staff and the Salvation Army band through Kangemi Central and Mountain View sub locations respectively and finally at the West-lands sub-county social hall. Invited guests and the general community members joined the staff in the procession. The function was officially opened by Dr Gaudensia Mutua, the KAVI-ICR KNH site manager. Entertainment from various groups and a real-life testimony from someone living with HIV were part of the day’s activities of which messages regarding HIV Vaccine research were highlighted. The Guest of honour was Dr Asmah Awadh (Sub-County Medical Officer of Health) who commended the efforts made by KAVI-ICR in the search for an HIV vaccine. The function was also graced by representatives from the International AIDS Vaccine Initiative (IAVI), Liverpool VCT, Kangemi health centre staff and various other stakeholders from the county government. The function ended at around 1 pm with closing remarks being made by Dr Lavinia Bwisa the KAVI-ICR Kangemi clinic site manager. Community members were offered HIV testing, as well as blood sugar and blood group testing. We thank all those who attended the function and made it a success as well as the media houses (K24, Kameme, Peoples daily and The STAR newspaper) that covered the activities.

 

World AIDS Vaccine Day - May 2015 

This years events took place at Kibira Sports Ground.

 World AIDS Vaccine Day, also known as HIV Vaccine Awareness Day, is observed

annually on May 18. HIV vaccine advocates mark the day by promoting the

continued urgent need for a vaccine to prevent HIV infection and AIDS. They

acknowledge and thank the thousands of volunteers, community members, health

professionals, supporters and scientists who are working together to find a safe and

effective AIDS vaccine and urge the international community to recognize the

importance of investing in new technologies as a critical element of a

comprehensive response to the HIV/AIDS epidemic.

 This years’ occasion was graced by KAVI-ICR Deputy Director Prof. Walter Jaoko,

Representative to the Deputy County Commissioner Lang’ata Sub-County,

WAC Director and Area Chief. The team went for a community sensitization

walk and there after various entertainment groups from Kibra made various

presentations to sensitize the community on the importance of the day.